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This is a terrible team of phishing scammers. They overstated the so called “World’s leading clone scripts” to induce people to buy. They are actually full of bugs and errors. They never got the issues fixed, and never refund you.

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Tailed spider trapped in 100-million-year old amber offers insight in evolution

A spider-like creature bearing a long tail has been discovered in an amber from Myanmar dating back about 100 million years.

"There's been a lot of amber being produced from northern Myanmar and its interest stepped up about ten years ago when it was discovered this amber was mid-Cretaceous," said Paul Selden, a palaeontologist at the University of Kansas and an author of a paper on the ancient arachnid.

"Therefore, all the insects found in it were much older than first thought," Selden told the university in an interview.

The finding is published Monday in a paper in Nature Ecology & Evolution by an international team of researchers from the United States, China, Germany and the United Kingdom.

According to the paper, the creature shares many similarities with modern spiders including fangs, eight legs and silk-producing spinners.

Moreover, it also bears a long flagellum, or a tail, at its rear, which is not commonly seen among modern spiders.

Thought the ancient arachnid has a tiny body, only about 2.5 millimeters long, it had a tail nearly twice of its body length.

"Any sort of flagelliform appendage tends to be like an antenna," Selden said, "It's for sensing the environment. Animals that have a long whippy tail tend to have it for sensory purposes."

The tailed arachnid, named Chimerarachne after the Greek mythological Chimera, documents a key transition stage in spider evolution.

Previously, Selden and his colleagues had found similar insects without spinnerets from the much older Devonian and Permian periods.

"That's why the new one is really interesting, apart from the fact that it's much younger -- it seems to be an intermediate form," Selden said.

"In our analysis, it comes out sort of in between the older one that hadn't developed the spinneret and modern spider that has lost the tail," he added.

Cloned monkeys could help development of drugs for human brain diseases

Chinese scientists' successful cloning of monkeys could eventually help the development of new drugs to treat human diseases, like brain and nervous system problems, a leading Chinese neuroscientist said.

At the end of 2017, a non-human primate research facility under the Beijing-based Chinese Academy of Sciences (CAS) produced two cloned macaques.

Allaying fears that cloning monkeys for research could ultimately lead to human cloning, Poo Muming, director of the Institute of Neuroscience at CAS, told Xinhua, "We have no intention to clone humans."

The macaque cloning was done for a humane reason, he said: "Because this is the species that will really help human health and cure human disease."

The cloning will reduce the use of large numbers of primates for research, especially in the West.

In 2016, the United States used over 71,000 primates for research or experimentation, according to the U.S. Department of Agriculture's animal and plant health inspection service.

U.S. pharmaceutical companies import at least 50,000 monkeys every year to test the efficacy of different drugs and determine safe doses for human clinical trials, Poo said.

"That is a huge number of monkeys used, which you should consider unethical," he said.

Since these monkeys have diverse genetic backgrounds, researchers must use a large number to make sure that the observed effects are due to treatment and not because of the genetic variation.

"Cloning is really the way to go," Poo said. "Because it reduces the interference (of) the diversity of genetic background on drug development. So it is for (that) ethical reason that we (have cloned) monkeys."

Darren Griffin, genetics professor at the University of Kent, holds the same view.

"If they can produce these cloned animals that means that you could use fewer animals for ... research, rather than the number being used at the moment," he said in a previous interview with Xinhua.

At present, the medical community mostly uses mice as a model to research cures for human diseases. But for many diseases, especially brain diseases, drugs that are developed using mice as model have failed clinical trials in humans, Poo said.

"Basically all big pharmas have given up developing neuro drugs," he said, citing two decades of drug development failure, with hundreds of billions of dollars spent on each drug.

"Next, we want to develop clones of animals that carry brain disorders," he said, especially degenerative or development diseases that have clear genetic causes.

Poo said he would like to focus on Alzheimer's, Parkinson's, autism and ALS, a nervous system disorder that causes disability.

Regarding the debate on the ethics of non-human primate cloning, he said every new technology is a two-edged sword: "There will be discussions and we'll see how the society deals with it."

In the 1970s, when genetic engineering technology first came out, he said everybody was worried about its harmful effect on humans.

"But so far, it has been 40 to 50 years and you don't see any real problem yet," he said.

"Cloned monkeys could be very valuable in studying specific aspects of human disease," said Tom Holder, director of Speaking of Research, an international organization that supports the use of animals in scientific labs.

"The breakthrough has shown that it is possible," Holder said in an emailed interview to Xinhua. "But it is too early to make any conclusions on whether the method will be able to be repeated efficiently and reliably."

Holder also said non-human primate research is subject to increased ethical and welfare considerations and is generally used only when other species are unsuitable for the research.

13 most reviewed Inout Scripts

Generally speaking, inoutscripts guys are a phishing scamming team. Their scripts are full of bugs and errors. Nothing is working. They did not give any effective support. Some of them are 10 years old without updating. 

If you are a victim of inoutscripts, please don't hesitate to contact me. Let's bring these bad guys to justice together.

Reviews:

1.     I have used most of these Inout Scripts. I purchased 13 of them.

2.     They are just liars, since they don't have the technology of big data. The hypertable/Hadoop is not working at all. It would take 50 years to fill 10 TB storage according to our calculation. The Inout spider can just crawl about 2000 pages per day.

3.     Some of the inourscripts can cause the server down, since they produce a ton of error log every day. 

4.     The sites are super slow. They will blame you whichever servers you use. I tried our own servers and bluehost. The results were the same. Our own sites have been running very fast.

5.     The inout search engine is not compatible with inout spider. It brings results not consistent with keywords.

6.     The inout scripts are not SEO. You can just get little traffic however you try.

7.     The webportal is not working. You'll never get something like Yahoo as they overstated.

8.     The cronjob of inoutscripts adserver is not working. The addons are not compatible.

9.     The inout articlebase has injection defects.

10. The inout celebrities is not responsive design. If you need a mobile mode, they will charge $480-800 as customization.

11. The inout queryspace is still using PHP 5.4 which is not supported by the official site.

12. The webmail ultimate can't be used to send or receive emails. It is a knid of malware that will get security warning from chrome and google.

13. I purchased 4 APPs, but they did not give me any one.

14. You can log into the inout socialtitles but can't log out from it sometimes. It does not have an email confirmation and recap feature. If you need these functions, they will charge you for customization. My site were attacked and spammed repeatedly.

15. They never refund you once you transfer the $$$. Yes, you'll never get any effective support from the staff.

16. Just a few of them here. I'll tell you uch more bugs and errors of Inout Scripts later.

The below are all the InoutScripts:

21 scripts in over 115 countries

All Advertising Solutions Search Solutions Email Solutions Portal Solutions Mobile Apps
Inout
Search Engine
Meta Search Engine Script with multiple API support. Google Clone.

Inout
Spider
Powerful Web Crawler Script. A Googlebot Clone for Small/Medium Business

Inout
Site Search
Fast & Simple Site Search. Let visitors find what they are looking for. Quickly!

Inout
Adserver
Ad serving & Ad Management Script. Adwords & Adsense Clone.

Inout
Email Marketer
Bulk Mailing & List Management Script. Reach Your Market directly.

Inout
PPC Engine
Powerful Ad management combined with standard Pay Per Click Script.

Inout
Webmail
Powerful Webmail solution for small business.

Inout
Support Desk Manager
Professional customer support & ticketing solution.

Inout
RealEstate
Premium Real Estate Property Management Script. Trulia/Realtor/Zillow Clone.

Inout
StickBoard
Premium Pin and Board Style Social Photo/Video Sharing Script.

Inout
EasyRooms
Space Rental and Vacation Rental Script. Airbnb Clone Script.

Inout
Shopping Cart
Multi-Vendor Shopping cart. Ready for eCommerce.

Inout
Music
Most powerful Music selling & sharing script on the market.

Inout
Video
Video Sharing Portal. A YouTube clone with Ads Enabled.

Inout
SmartDeal
Group Deals Script. A Groupon & LivingSocial Clone.

Inout
Queryspace
Question & Answer Script.

Inout
CareerLamp™
Meticulously Designed Job Portal Website. A Monster.com Clone.

Inout
Web Portal
Start your own Web Portal.Combine multiple scripts

Inout
SocialTiles
Social Media Clone Script. Facebook Clone Script.

Inout
Article Base
Content Management System (CMS). Blogs, articles and more.

Inout
Celebrities
Gossip, News & More. Premium Entertainment Portal

ioMob
Tunes
Most Powerful Music Selling & Sharing Script on the Market.

ioMob
Cart
eCommerce Mobile App for small to medium businesses around the world.

ioMob
Rooms
App for easy and flexible Vacation & Space Rentals.

Inoutscripts Search Engine v8 on Sale, 85% off

I purchased Inoutscripts Search Engine v8 addons $1070 one year ago. This is the most updated edition. Most of the bugs and errors were fixed by support@inoutscripts.com. Jacob and Kumar are in charge of this Indian company, and they promised to get everything fixed as soon as possible.

If you are prefer, I would like to let you have the license for just $160 totally, 85% off. It's a very good price. You will enjoy the script with this world leading inspired clone scripts company in Kerala India. They said they are not phishing scammers.

If you are interested, feel free to contact me. Thanks

Search engine v8 with above compatible addons cost : 1070 USD

Search engine v8  ：449 USD

google theme: 175 USD

language translator： 99 USD

search maps: 149 USD

social plugin: 99 USD

social tab addon: 99 USD

Inout Scripts Webmail Ultimate on Sale, 85% off

I purchased Webmail Ultimate Edition+addon  :497+149  USD = $646 one year ago. This is the most updated edition. Most of the bugs and errors were fixed by support@inoutscripts.com. Jacob and Kumar are in charge of this Indian company, and they promised to get everything fixed as soon as possible.

If you are prefer, I would like to let you have the license for just $96 totally, 85% off. It's a very good price. You will enjoy the script with this world leading inspired clone scripts company in Kerala India. They said they are not phishing scammers.

If you are interested, feel free to contact me. Thanks

Adipogenic Differentiation from Mesenchymal Stem Cell (MSCs) Involves PTHrP and PPAR-γ Pathways

Background: The potential use of cell-based therapy is one of the most exciting advances in the field of translational medicine to treat various pathological conditions that have been untreatable up to now. Chronic lung disease is rapidly becoming the primary cause of death in the US. Currently, there is no intervention that can either arrest or cure evolving or established chronic lung diseases. Knowledge of the intrinsic molecular mechanisms that allow for resistance to inflammation and recruitment of stem cells for repair would allow for the engineering of such cells for effective treatment.

MSCs are bone marrow non-haematopoietic stem cells that are multipotent and can differentiate into bone, cartilage and connective tissues. Moreover MSCs present many advantages as facilities to culture or to transform genetically. We have discovered that Parathyroid Hormone-related Protein (PTHrP) and PPAR-r drive the key homeostatic lung epithelial-mesenchymal interactions, resulting in the differentiation of alveolar interstitial lipofibroblasts that are essential for normal lung development and its repair following injury. In this paper, we try to isolate CD45 (-) CD73 (+) CD90 (+) MSCs from 6 weeks old rats and further induce such cells into adipogenic cells. Meanwhile, we try to confirm our hypothesis that PTHrP and PPAR-γ related pathways are involved in the MSCs differential procedure.

Methods:  Femurs and tibias were aseptically harvested from 6 weeks old Wistar rats. Whole bone marrow plugs were obtained by flushing the bone marrow cavity with an 18-gauge needle set with a syringe filled with α-MEM medium. Second passage of adherent MSCs were analyzed by flow cytometry after staining with fluorochrome conjugated CD45, CD73 and CD90 antibodies. These MSCs had been inducing with induction buffer (α-MEM enriched with 10% FBS, 10 μg/ml insulin, 1 μM dexamethasone, and 0.5 mM 3-isobutyl-1-methylxanthine for 11 days. Oil Red O stain was processed to show the efficacy of adipocytic induction. Total RNA was extracted with one step procedure, and RT-PCR was used to probe PPAR-γ expression. Also, we investigated the muscular marker, α-SMA, by Western blot hybridization.

Results: The BM-derived MSCs expressed a set of specific markers that are well-known to define MSCs, including 99.36% CD45 (-), 59.92 CD73 (+), and 91.1% CD90 (+). Adipocytic differentiation of rat MSCs was induced under the conditions described above. Morphologically, the spindle small MSCs changed into large round cells with alveolus-like distribution.  Appearance of cell fat granules was observed after 11 days incubation. More than 50% of the induced cells displayed Oil Red O+ lipid granules, and 500 nM PTHrP and 1 nM RGZ obviously increased the Oil Red O+ cells with more and larger lipid granules. PPAR-γ, a marker of adipocylic differentian, was over expressed after induction with/without enhancement (PTHrP or RGZ, or both). On the other hand, the muscular marker, α-SMA had much lower expression after the induction. The groups with PTHrP and/or RGZ had significant weaker α-SMA expression, comparatively.

Conclusion: Adherent MSCs isolated from 6 weeks old rat can be directionally induced into adipocytic cells. PTHrP and PPAR-γ stimulator RGZ can enhance this kind of differentiation.