- 2018- James P Allison and Tasuku Honjo for Immune
checkpoint therapy to treatments for advanced, deadly cancers.
- 2017- Jeffrey Hall,
Michael Rosbash and Michael Young for unravelling how bodies keep a
circadian rhythm or body clock
- 2016 - Yoshinori
Ohsumi for discovering how cells remain healthy by
recycling waste.
- 2015 - William C
Campbell, Satoshi Ōmura and Youyou Tu for anti-parasite drug
discoveries.
- 2014 - John O'Keefe,
May-Britt Moser and Edvard Moser for discovering the brain's
navigating system.
- 2013 - James Rothman,
Randy Schekman, and Thomas Sudhof for their discovery of how cells precisely transport
material.
- 2012 - Two pioneers
of stem cell research - John Gurdon and Shinya Yamanaka - were awarded the
Nobel after changing
adult cells into stem cells.
- 2011 - Bruce Beutler,
Jules Hoffmann and Ralph Steinman shared the prize after revolutionising
the understanding of how the body fights
infection.
- 2010 - Robert Edwards
for devising the
fertility treatment IVF which led to the first "test tube
baby" in July 1978.
- 2009 - Elizabeth
Blackburn, Carol Greider and Jack Szostak for finding the telomeres at the ends
of chromosomes.
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Wednesday, October 3, 2018
Most Recent 10 Nobel's Prizes for Medicine or Physiology
2018 Nobel prize for medicine or Physiology goes to immune checkpoint therapy
Two
scientists who discovered how to fight cancer using the body's immune system
have won the 2018 Nobel Prize for physiology or medicine.
The
work, by Professor James P Allison from the US
and Professor Tasuku Honjo from Japan ,
has led to treatments for advanced, deadly skin cancer.
Immune
checkpoint therapy has revolutionised cancer treatment, said the prize-giving Swedish Academy .
Experts
say it has proved to be "strikingly effective".
Prof
Allison, of the University of Texas , and Prof Honjo, of Kyoto University ,
will share the Nobel prize sum of nine million Swedish kronor - about $1.01
million or 870,000 euros.
Accepting
the prize, Tasuku Honjo told reporters: "I want to continue my research
... so that this immune therapy will save more cancer patients than ever."
Prof
Allison said: "It's a great, emotional privilege to meet cancer patients
who've been successfully treated with immune checkpoint blockade. They are
living proof of the power of basic science, of following our urge to learn and
to understand how things work."
Treating
the untreatable
Our
immune system protects us from disease, but it has built-in safeguards to stop
it from attacking our own tissue.
Some
cancers can take advantage of those "brakes" and dodge the attack
too.
Allison
and Honjo, now both in their 70s, discovered a way to unleash our immune cells
to attack tumours by turning off proteins that put the brakes on.
And
that led to the development of new drugs which now offer hope to patients with
advanced and previously untreatable cancer.
Immune
checkpoint therapy is being used by the NHS to treat people with the most
serious form of skin cancer, melanoma.
It
doesn't work for everyone, but for some patients it appears to have
worked incredibly
well, getting rid of the tumour entirely, even after it had started to
spread around the body.
Such
remarkable results had never been seen before for patients like these.
Doctors
have also been using the treatment to help some people with advanced lung
cancer.
Prof
Charles Swanton, from Cancer Research UK , congratulated the prize
winners, saying: "Thanks to this groundbreaking work, our own immune
system's innate power against cancer has been realised and harnessed into
treatments that continue to save the lives of patients. For cancers such as
advanced melanoma, lung, and kidney, these immune-boosting drugs have
transformed the outlook for many patients who had run out of options.
"The
booming field of immunotherapy that these discoveries have precipitated is
still relatively in its infancy, so it's exciting to consider how this research
will progress in the future and what new opportunities will arise."
Medicine
is the first of the Nobel Prizes awarded each year.
The
literature prize will not be handed out this year, after the awarding body
was affected by
a sexual misconduct scandal.
By Michelle RobertsHealth editor, BBC News online
Sunday, March 25, 2018
Biodiversity worsens all over the world, in urgency to cope with
An intergovernmental ecological body said on Friday that the biodiversity, the essential variety of life forms on Earth, continued to decline in every region of the world, significantly reducing nature’s capacity to contribute to people’s well-being.
Those alarming trends are endangering economies, livelihoods, food security and the quality of life of people everywhere, according to four peer-reviewed regional reports released by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES).
Human-induced climate change, which affects temperature, precipitation and the nature of extreme events, is increasingly driving biodiversity loss and the reduction of nature’s contributions to people, said Jake Rice, a co-chair of the Americas assessment.
In the Americas, the populations of species are about 31 percent smaller than those was at the time of European colonization, according the report. With the growing effects of climate change added to the other drivers, this loss is projected to reach 40 percent by 2050, it says.
In Africa, by 2100, climate change could also result in the loss of more than half of African bird and mammal species, a 20 to 30 percent decline in the productivity of Africa’s lakes and significant loss of African plant species.
The most recent sad example went to the death of the world’s only remaining male northern white rhino in Kenya on Monday. Its death left only two female northern white rhinos on the planet.
There have been some good news in Asia, however. Over the past 25 years, marine protected areas in the region increased by almost 14 percent and terrestrial protected area by 0.3 percent. Its forest coverage increased by 2.5 percent, with the highest increases in North East Asia (22.9 percent) and by South Asia (5.8 percent).
But the report considered those efforts in Asia insufficient to halt the loss of biodiversity. Unsustainable aquaculture practices, overfishing and destructive harvesting, threaten coastal and marine ecosystems, with projections that, if current fishing practices continue, there will be no exploitable fish stocks in the region by 2048.
Also in Asia, intertidal zones are also rapidly deteriorating due to human activities as up to 90 percent of corals will suffer severe degradation by 2050, even under conservative climate change scenarios.
In the European Union, only 7 percent of marine species and 9 percent of marine habitat types have shown a “favorable conservation status.” Moreover 27 percent of species assessments and 66 percent of habitat types assessments show an “unfavorable conservation status.”
“One of the most important findings across the four IPBES regional assessments is that failure to prioritize policies and actions to stop and reverse biodiversity loss, and the continued degradation of nature’s contributions to people,” said Anne Larigauderie, the Executive Secretary of IPBES.
“Tools like these four regional assessments provide scientific evidence for better decision making and a path we can take forward to achieve the Sustainable Development Goals and harness nature’s power for our collective sustainable future,” said Achim Steiner, Administrator of United Nations Development Program.
Wednesday, February 14, 2018
Clues to aging found in stem cells' genomes
Stem cells that produce sperm use a genetic trick to stay perpetually young across generations, researchers at the University of Michigan (UM) Life Sciences Institute have discovered.
The results have been newly reported in the journal eLife.
Certain sections of the fruit fly genome get shorter with age. But remarkably, some reproductive cells can repair the shrinkage, and this genomic shrinkage may underlie aspects of aging and hint at ways that select cells might thwart it.
In the study, UM researchers focused on workhorse genes encoded in ribosomal DNA, or rDNA. These genes carry instructions for the parts that make up ribosomes, cellular machines that turn RNA molecules into every protein needed in the body.
In fruit flies, chains of rDNA genes are found on the X and Y chromosomes. Compared with young male fruit flies, old males had a shortage of rDNA genes on the Y chromosome, leaving them with a shrunken Y chromosome.
Moreover, this dearth of rDNA seems to be passed on from generation to generation. Geriatric fly fathers, those 40 days old, passed on their reduced number of rDNA genes to their sons, UM researchers found. These sons had considerably fewer copies of rDNA genes than sons born to younger fathers.
Then the researchers saw something surprising. In many cases, this rDNA loss reversed itself. At about 10 days of age, sons born to old fathers had recovered enough rDNA to be comparable to sons born to young fathers.
"This recovery was something we really didn't expect," said UM Life Sciences Institute faculty member Yukiko Yamashita.
The results suggest that rDNA rejuvenation in sons might be a crucial aspect of how stem cells persist from father to son. The researchers do not yet know whether such a reset can happen to female stem cells in the ovaries.
Until now, researchers had observed the phenomenon only in yeast. If the results hold true for humans, they could offer insight into how most cells deteriorate over time.
Being pushed, Yamashita would wager that some types of immortal cells in people can perform the same rejuvenating trick to prevent the rDNA declines that come with age.
1 error and 134 warnings? What happened with inout Scripts Adser.
I checked the Inout Scripts Adserver
script with http://infohound.net/tidy/. To my surprise, there are still 1 error
and 134 warnings with it after 15 months troubleshooting with Inoutscripts supporters
Nair and Saranya.
In addition, most of the addons are
not working at all.
The inoutscripts software has
security vurnerability. It had been attacked 3 times.
These Inout Scripts Scammers had
never got these bug fixed. They just took cash and left me nothing working.
Monday, February 12, 2018
DNA Cloning
In biology a clone is a
group of individual cells or organisms descended from one progenitor. This
means that the members of a clone are genetically identical, because cell
replication produces identical daughter cells each time. The use of the word clone has
been extended to recombinant DNA technology, which has provided scientists with
the ability to produce many copies of a single fragment of DNA, such as a gene,
creating identical copies that constitute a DNA clone. In practice the
procedure is carried out by inserting a DNA fragment into a small DNA molecule
and then allowing this molecule to replicate inside a simple living cell such
as a bacterium. The small replicating molecule is called a DNA vector
(carrier). The most commonly used vectors are plasmids (circular DNA
molecules that originated from bacteria), viruses, and yeast cells.
Plasmids are not a part of the main cellular genome, but they can carry genes
that provide the host cell with useful properties, such as drug resistance,
mating ability, and toxin production. They are small enough to be conveniently
manipulated experimentally, and, furthermore, they will carry extra DNA that is
spliced into them.
Recombinant DNA technology
Recombinant DNA technology, joining
together of DNA molecules
from two different species that are inserted into a host organism to produce
new genetic combinations that are of value to science, medicine, agriculture,
and industry. Since the focus of all genetics is the gene, the fundamental goal
of laboratory geneticists is to isolate, characterize, and manipulate genes.
Although it is relatively easy to isolate a sample of DNA from a collection of cells, finding a
specific gene within this DNA sample can be compared to finding a needle in a
haystack. Consider the fact that each human cell contains approximately 2
metres (6 feet) of DNA. Therefore, a small tissue sample will contain many
kilometres of DNA. However, recombinant DNA technology has made it possible to
isolate one gene or any other segment of DNA, enabling researchers to determine
its nucleotide sequence,
study its transcripts, mutate it in highly specific ways, and reinsert the
modified sequence into a living organism.
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